Some novel Oxazine substituted benzimidazoles (4a-j) were synthesized via hetero cyclization of the key intermediate of chalcone derivatives of benzimidazoles (3a-j) with urea. The structures of new synthesized compounds were characterized and confirmed by TLC, elemental analysis, IR and 1HNMR Spectroscopy. All the final products were also screened invitro for their antimicrobial activities by Cup - Plate Method. Almost all the synthesized compounds exhibited significant activity against various bacterial and fungal stains.
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